Protein Phosphorylation Antibody Pairs
Gibco™ Floor Plate Cell Expansion Kit
The Floor Plate Cell Expansion Kit is a component of the Gibco™ PSC Dopaminergic Neuron Differentiation Kit that is also offered separately.
Cell Signaling Technology PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 10 Kit
PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 10 Kit
ABclonal Technology CDKN1B/p27KIP1 Rabbit pAb
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Cell Signaling Technology FastScantm Phospho-Akt1 Ser473 ELISA Kit 20 Kit
FastScantm Phospho-Akt1 Ser473 ELISA Kit 20 Kit
ABclonal Technology Phospho-Raf1-S621 Rabbit pAb
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
ABclonal Technology Phospho-NF-B p105-S932
This gene encodes a 105 kD protein that is processed by the 26S proteasome into a 50 kD protein The 105 kD protein acts as a Rel protein-specific transcription inhibitor while the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB activated by stimuli like cytokines UV irradiation and bacterial or viral products regulates various biological functions Once activated NFKB translocates to the nucleus to stimulate gene expression Inappropriate NFKB activation is linked to inflammatory diseases while its inhibition can disrupt immune cell development and delay cell growth NFKB also regulates the early response to viral infections Alternative splicing generates multiple isoforms including proteolytically processed variants
ABclonal Technology Phospho-AKT1-T308 Rabbit pAb
This gene encodes a member of the AKT serine-threonine kinase family, which regulates key cellular functions such as cell proliferation, survival, metabolism, and angiogenesis. AKT proteins are activated by phosphorylation through the PI3K pathway and play a central role in signaling involving receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinases. Activation of AKT involves phosphorylation of specific residues, including threonine 308 and serine 473. AKT also participates in the mTOR pathway, which is crucial for translation initiation and often dysregulated in cancers. Mutations in this gene are linked to multiple cancers, including breast, colorectal, and ovarian, as well as conditions like Proteus and Cowden syndrome. Alternative splicing of this gene results in multiple transcript variants.
ABclonal Technology Phospho-Raf1-S621 Rabbit pAb
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
ABclonal Technology Phospho-NFKB1-S337 Rabbit pAb
This gene encodes a 105 kD protein that undergoes cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein inhibits Rel protein-specific transcription, while the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) complex. NFKB is activated by various stimuli like cytokines, oxidative stress, and microbial products, and translocates to the nucleus to regulate genes involved in numerous biological processes. Aberrant NFKB activation is linked to inflammatory diseases, while persistent inhibition can cause immune dysfunction or delayed cell growth. NFKB is also essential in the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants, with at least one being proteolytically processed.
Cell Signaling Technology FastScantm Phospho-SMAD2 Ser465467 ELISA Kit 50 Kit
FastScantm Phospho-SMAD2 Ser465467 ELISA Kit 50 Kit
Cell Signaling Technology PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 50 Kit
PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 50 Kit
Cell Signaling Technology Phospho-SMAD2 Ser465467 Matched Antibody Pair 1 Kit
Phospho-SMAD2 Ser465467 Matched Antibody Pair 1 Kit
ABclonal Technology Phospho-AKT1-T308 Rabbit pAb
This gene encodes one of three AKT serine-threonine kinases (AKT1, AKT2, AKT3), essential in regulating various cellular functions such as proliferation, survival, metabolism, and angiogenesis. AKT proteins have a pleckstrin homology domain, a kinase domain, and a regulatory domain. They are activated by phosphorylation through PI3K and are recruited to the cell membrane by PIP3. Activation requires phosphorylation at threonine 308 and serine 473, with additional phosphorylation in response to growth factors like IGF-1 and EGF. AKT1 is a key component in the PI3K/AKT signaling pathway, regulating tumor cell survival and apoptosis. AKT also participates in the mTOR pathway, which is crucial for protein synthesis. Mutations in this gene are linked to cancers (e.g., breast, ovarian, colorectal) and disorders like Proteus and Cowden syndromes. Alternative splicing produces different isoforms of this gene.
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 20 Kit
PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 20 Kit
ABclonal Technology Phospho-STK11-S334 Rabbit pAb
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.